SMALL BOWEL ULCERS – A RARE CAUSE OF MASSIVE DIGESTIVE HAEMORRHAGE: CASE REPORT

  • Florin Bobirca Carol Davila university of Medicine and Pharmacy
  • Anca Bobircă Internal Medicine and Rheumatology Department, “Dr Ion Cantacuzino” Clinical Hospital, Bucharest, Romania & “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
  • Dan Dumitrescu General Surgery Department, “Dr Ion Cantacuzino” Clinical Hospital, Bucharest, Romania
  • Lidia Belega General Surgery Department, “Dr Ion Cantacuzino” Clinical Hospital, Bucharest, Romania
  • Romina Marina Sima Obstetrics and Gynecology Department, “Sfântul Ioan” Emergency Hospital, Bucharest, Romania & “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
  • Traian Pătrașcu General Surgery Department, “Dr Ion Cantacuzino” Clinical Hospital, Bucharest, Romania & “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Keywords: small bowel ulcers, digestive haemorrhage, non-steroidal anti-inflammatory medication

Abstract

Ulcerations of the small bowel represent a lack of substance of the intestine wall, which comprises or exceeds the submucous layer. The frequency of their occurrence is low: 40-50 for 100,000 inhabitants/year. Most of the times, they have ranging between 0.4 - 4 cm in diameter and occur more frequently at the level of the terminal ileum, especially on the antimesostenic edge, because vascularization is lower at this level by comparison to the mesostenic edge. Multiple ulcerations of large size may be accompanied by a vital complication, namely massive bleeding, for which the therapeutic attitude implies, in most cases, the association of surgical treatment. A patient of 61 years of age, diabetic, at a phase of multiple cardio-vascular and visceral complications, who, after having followed an intensive treatment with non-steroid anti-inflammatory medication 4 tablets / day for a week, is showing an episode of massive digestive haemorrhage with a decrease in haemoglobin values from 11.3 g/dl down to 5.6 g/dl and for whom the therapeutic solution was represented by surgical intervention with segmental enterectomy for multiple bleeding ulcerative lesions of the ileum. The post-operatory evolution has been a positive one, normal haemoglobin values have been re-established. Although massive digestive haemorrhages having as source ulcerations of the small bowel represent life threatening situations, permanent monitoring of the patient in the intensive care unit, careful hydro-electrolytic rebalancing, blood transfusions as well as surgical treatment applied at the right time may lead to a favourable outcome.

References

1. Rosen CM, Raskin JB: Small intestinal ulcers. In Clinical practice of Gastroenterology, vol 1. Edited by Brandt LJ. Philadelphia: Churchill Livingstone; 1999:502–506.
2. Keuchel M, Kurniawan N, Baltes P. Small bowel ulcers: when is it not inflammatory bowel disease ? Curr Opin Gastroenterol. 2019 May;35(3):213-222. doi: 10.1097/MOG.0000000000000522. PMID: 30865040.
3. Arieira C, Dias de Castro F, Boal Carvalho P, Rosa B, Moreira MJ, Cotter J. Small-bowel transit time in capsule endoscopy: a determinant factor for the diagnosis of small-bowel bleeding. Rev Esp Enferm Dig. 2021 Oct;113(10):709-713. doi: 10.17235/reed.2021.7487/2020. PMID: 33486962.
4. Rai R, Bayless TM: Isolated and diffuse ulcers of the small intestine. In Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management, edn 6. Edited by Feldman M, Sleisenger MH, Scharschmidt BF. Philadelphia: WB Saunders; 1998:1771–1778.
5. Bjarnason I, Hopkinson N, Zanelli G, et al.: Treatment of nonsteroidal anti-inflammatory drug induced enteropathy. Gut 1990, 31:777–780
6. Matsuhashi N, Yamada A, Hiraishi M, et al.: Multiple strictures of the small intestine after long-term nonsteroidal anti-inflammatory drug therapy. Am J Gastroenterol 1992, 87:1183–1186
7. Savides TJ, Jensen DM. Gastrointestinal Bleeding. In: Feldman M, Frience S,Brandt LJ, editors. Sleisenger and Fordtran’s Gastrointestinal and Liver Disease. 9th Edition. Elsevier Medicine 2010.
8. Singh A, Baptista V, Stoicov C, et al. Evaluation of small bowel bleeding. Curr Opin Gastroenterol 2013;29:119-24.
9. Popescu I. et al. Surgical Treaty, Small Bowel Ulcers, Romanian Academy Ed., 2009, 101-102.
Published
2022-12-29