THE CHALLENGING MANAGEMENT OF ACUTE MESENTERIC ISCHEMIA: A CASE REPORT OF A 45-YEAR-OLD WOMAN WITH SHORT BOWEL SYNDROME

  • Andreea Pușcașu Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
  • Dan Nicolae Păduraru Carol Davila University of Medicine and Pharmacy, Bucharest, Romania & University Emergency Hospital of Bucharest, Romania
  • Alexandra Bolocan Carol Davila University of Medicine and Pharmacy, Bucharest, Romania & University Emergency Hospital of Bucharest, Romania
  • Daniel Ion Carol Davila University of Medicine and Pharmacy, Bucharest, Romania & University Emergency Hospital of Bucharest, Romania
  • Florentina Mușat Carol Davila University of Medicine and Pharmacy, Bucharest, Romania & General Surgery Department of University Emergency Hospital of Bucharest, Romania
  • Octavian Andronic Carol Davila University of Medicine and Pharmacy, Bucharest, Romania & General Surgery Department of University Emergency Hospital of Bucharest, Romania & Research Institute of the University of Bucharest, Bucharest, Romania
Keywords: acute mesenteric ischemia, short bowel syndrome, parenteral nutrition

Abstract

This case report explores the fatal prognosis of acute mesenteric ischemia leading to short bowel syndrome in a 45-year-old female patient. Acute mesenteric ischemia, a rare but critical condition, is caused by impaired blood flow to the intestines, necessitating prompt diagnosis and treatment to mitigate high mortality risks. The patient's case is complex, involving multiple surgeries for ischemic bowel resection, resulting in short bowel syndrome, characterized by a severe reduction in functional intestinal length. This syndrome presents significant challenges, including malnutrition and the necessity for long-term parenteral nutrition, which are difficult to manage and significantly impair quality of life. Despite surgical success in bowel resection, the patient's condition deteriorated due to complications from short bowel syndrome and resulted in her death six months post-surgery. This report underscores the need for early diagnosis and intervention in acute mesenteric ischemia, the limitations of current surgical treatments, and the dire consequences of short bowel syndrome. It also highlights the potential yet limited role of intestinal transplantation in managing these complex cases.

References

[1] A. Patel, R. N. Kaleya, and R. J. Sammartano, “Pathophysiology of Mesenteric Ischemia,” Surgical Clinics of North America, vol. 72, no. 1, pp. 31–41, Feb. 1992, doi: 10.1016/S0039-6109(16)45626-4.
[2] A. Gragossian, M. E. Shaydakov, and P. Dacquel, “Mesenteric Artery Ischemia,” StatPearls, Aug. 2022. Available: https://www.ncbi.nlm.nih.gov/books/NBK513354/
[3] “Acute mesenteric ischemia natural history, complications and prognosis - wikidoc.”. Available: https://www.wikidoc.org/index.php/Acute_mesenteric_ischemia_natural_history,_complications_and_prognosis
[4] W. A. Oldenburg, L. L. Lau, T. J. Rodenberg, H. J. Edmonds, and C. D. Burger, “Acute mesenteric ischemia: a clinical review,” Arch Intern Med, vol. 164, no. 10, pp. 1054–1062, May 2004, doi: 10.1001/ARCHINTE.164.10.1054.
[5] M. Bala et al., “Acute mesenteric ischemia: Guidelines of the World Society of Emergency Surgery,” World Journal of Emergency Surgery, vol. 12, no. 1, pp. 1–11, Aug. 2017, doi: 10.1186/S13017-017-0150-5/FIGURES/3.
[6] K. S. Choi et al., “Percutaneous Aspiration Embolectomy Using Guiding Catheter for the Superior Mesenteric Artery Embolism,” Korean J Radiol, vol. 16, no. 4, pp. 736–743, Aug. 2015, doi: 10.3348/KJR.2015.16.4.736.
[7] M. Bala et al., “Acute mesenteric ischemia: guidelines of the World Society of Emergency Surgery”, doi: 10.1186/s13017-017-0150-5.
[8] S. Florim, A. Almeida, D. Rocha, and P. Portugal, “Acute mesenteric ischaemia: a pictorial review,” Insights Imaging, vol. 9, no. 5, pp. 673–682, Oct. 2018, doi: 10.1007/S13244-018-0641-2/FIGURES/12.
[9] M. A. Mansour, “Management of acute mesenteric ischemia,” Arch Surg, vol. 134, no. 3, pp. 328–331, 1999, doi: 10.1001/ARCHSURG.134.3.328.
[10] A. J. Aschoff et al., “Evaluation of acute mesenteric ischemia: accuracy of biphasic mesenteric multi-detector CT angiography,” Abdominal Imaging 2008 34:3, vol. 34, no. 3, pp. 345–357, Apr. 2008, doi: 10.1007/S00261-008-9392-8.
[11] G. C. Hunter and J. M. Guernsey, “Mesenteric Ischemia,” Medical Clinics of North America, vol. 72, no. 5, pp. 1091–1115, Sep. 1988, doi: 10.1016/S0025-7125(16)30731-3.
[12] G. Salamone et al., “Non-occlusive mesenteric Ischemia (NOMI) in Parkinson’s disease: Case report,” Giornale di Chirurgia, vol. 38, no. 2, pp. 71–76, 2017, doi: 10.11138/gchir/2017.38.2.071.
[13] R. N. Kaleya, R. J. Sammartano, and S. J. Boley, “Aggressive approach to acute mesenteric ischemia,” Surg Clin North Am, vol. 72, no. 1, pp. 157–182, 1992, doi: 10.1016/S0039-6109(16)45633-1.
[14] E. Sulger, H. S. Dhaliwal, A. Goyal, and L. Gonzalez, “Mesenteric Venous Thrombosis,” StatPearls, Jul. 2022. Available: https://www.ncbi.nlm.nih.gov/books/NBK459184/
[15] I. G. Schoots, G. I. Koffeman, D. A. Legemate, M. Levi, and T. M. Van Gulik, “Systematic review of survival after acute mesenteric ischaemia according to disease aetiology,” Br J Surg, vol. 91, no. 1, pp. 17–27, Jan. 2004, doi: 10.1002/BJS.4459.
[16] P. Kougias, D. Lau, H. F. el Sayed, W. Zhou, T. T. Huynh, and P. H. Lin, “Determinants of mortality and treatment outcome following surgical interventions for acute mesenteric ischemia,” J Vasc Surg, vol. 46, no. 3, pp. 467–474, Sep. 2007, doi: 10.1016/J.JVS.2007.04.045.
[17] F. Kühn, T. S. Schiergens, and E. Klar, “Acute Mesenteric Ischemia,” Visc Med, vol. 36, no. 4, pp. 256–263, Aug. 2020, doi: 10.1159/000508739.
[18] M. C. Wyers, “Acute mesenteric ischemia: diagnostic approach and surgical treatment,” Semin Vasc Surg, vol. 23, no. 1, pp. 9–20, Mar. 2010, doi: 10.1053/J.SEMVASCSURG.2009.12.002.
[19] M. Bala et al., “Acute mesenteric ischemia: Guidelines of the World Society of Emergency Surgery,” World Journal of Emergency Surgery, vol. 12, no. 1, pp. 1–11, Aug. 2017, doi: 10.1186/S13017-017-0150-5/FIGURES/3.
[20] T. W. Carver, R. S. Vora, and A. Taneja, “Mesenteric Ischemia,” Crit Care Clin, vol. 32, no. 2, pp. 155–171, Apr. 2016, doi: 10.1016/J.CCC.2015.11.001.
[21] A. L. Menges, K. Stoklasa, L. Meuli, B. Reutersberg, and A. Zimmermann, “Chronic Mesenteric Ischemia,” Gefasschirurgie, vol. 27, no. 6, pp. 435–443, Aug. 2022, doi: 10.1007/s00772-022-00931-z.
[22] D. Yildirim, A. Hut, C. Tatar, T. Donmez, M. Akinci, and M. Toptas, “Prognostic factors in patients with acute mesenteric ischemia,” Turk J Surg, vol. 33, no. 2, p. 104, 2017, doi: 10.5152/UCD.2016.3534.
[23] J. S. Thompson, J. K. DiBaise, K. R. Iyer, M. Yeats, and D. L. Sudan, “Postoperative Short Bowel Syndrome,” J Am Coll Surg, vol. 201, no. 1, pp. 85–89, Jul. 2005, doi: 10.1016/j.jamcollsurg.2005.02.034.
[24] A. Sitges-Serra, X. Mas, F. Roqueta, J. Figueras, and F. Sanz, “Mesenteric infarction: an analysis of 83 patients with prognostic studies in 44 cases undergoing a massive small-bowel resection,” British Journal of Surgery, vol. 75, no. 6, pp. 544–548, Dec. 2005, doi: 10.1002/bjs.1800750614.
[25] M. Cavicchi, P. Beau, P. Crenn, C. Degott, and B. Messing, “Prevalence of Liver Disease and Contributing Factors in Patients Receiving Home Parenteral Nutrition for Permanent Intestinal Failure,” Ann Intern Med, vol. 132, no. 7, p. 525, Apr. 2000, doi: 10.7326/0003-4819-132-7-200004040-00003.
[26] C. L. Donohoe and J. V. Reynolds, “Short bowel syndrome,” The Surgeon, vol. 8, no. 5, pp. 270–279, Oct. 2010, doi: 10.1016/j.surge.2010.06.004.
[27] M. T. Siddiqui, W. Al‐Yaman, A. Singh, and D. F. Kirby, “Short‐Bowel Syndrome: Epidemiology, Hospitalization Trends, In‐Hospital Mortality, and Healthcare Utilization,” Journal of Parenteral and Enteral Nutrition, vol. 45, no. 7, pp. 1441–1455, Sep. 2021, doi: 10.1002/jpen.2051.
[28] L. E. Matarese, S. J. O’Keefe, H. M. Kandil, G. Bond, G. Costa, and K. Abu‐Elmagd, “Short Bowel Syndrome: Clinical Guidelines for Nutrition Management,” Nutrition in Clinical Practice, vol. 20, no. 5, pp. 493–502, Oct. 2005, doi: 10.1177/0115426505020005493.
[29] C. F. Brandt et al., “Home Parenteral Nutrition in Adult Patients With Chronic Intestinal Failure: The Evolution Over 4 Decades in a Tertiary Referral Center,” Journal of Parenteral and Enteral Nutrition, vol. 41, no. 7, pp. 1178–1187, Sep. 2017, doi: 10.1177/0148607116655449.
[30] J. Nightingale, “Guidelines for management of patients with a short bowel,” Gut, vol. 55, no. suppl_4, pp. iv1–iv12, Aug. 2006, doi: 10.1136/gut.2006.091108.
[31] S. Massironi, F. Cavalcoli, E. Rausa, P. Invernizzi, M. Braga, and M. Vecchi, “Understanding short bowel syndrome: Current status and future perspectives,” Digestive and Liver Disease, vol. 52, no. 3, pp. 253–261, Mar. 2020, doi: 10.1016/j.dld.2019.11.013.
[32] B. Bielawska and J. Allard, “Parenteral Nutrition and Intestinal Failure,” Nutrients, vol. 9, no. 5, p. 466, May 2017, doi: 10.3390/nu9050466.
[33] F. Adaba et al., “Mesenteric Infarction,” Ann Surg, vol. 262, no. 6, pp. 1059–1064, Dec. 2015, doi: 10.1097/SLA.0000000000001100.
[34] D. A. J. Lloyd, R. Vega, P. Bassett, A. Forbes, and S. M. Gabe, “Survival and dependence on home parenteral nutrition: experience over a 25-year period in a UK referral centre,” Aliment Pharmacol Ther, vol. 24, no. 8, pp. 1231–1240, Oct. 2006, doi: 10.1111/J.1365-2036.2006.03106.X.
[35] A. Ukleja and M. M. Romano, “Complications of Parenteral Nutrition,” Gastroenterol Clin North Am, vol. 36, no. 1, pp. 23–46, Mar. 2007, doi: 10.1016/j.gtc.2007.01.009.
[36] A. Lemma et al., “Potential for intestinal transplantation after acute mesenteric ischemia in patients aged less than 70 years: A population-based study,” Scandinavian Journal of Surgery, vol. 112, no. 2, pp. 77–85, Jun. 2023, doi: 10.1177/14574969231151374/ASSET/IMAGES/LARGE/10.1177_14574969231151374-FIG2.JPEG.
[37] S. Kesseli and D. Sudan, “Small Bowel Transplantation,” Surgical Clinics of North America, vol. 99, no. 1, pp. 103–116, Feb. 2019, doi: 10.1016/j.suc.2018.09.008.
[38] D. Sudan, “Long-term outcomes and quality of life after intestine transplantation,” Curr Opin Organ Transplant, vol. 15, no. 3, pp. 357–360, Jun. 2010, doi: 10.1097/MOT.0b013e3283398565.
Published
2023-12-21