• Laura Popa „Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
  • Florentina Mușat General Surgery Department, University Emergency Hospital of Bucharest, Romania
  • D.N. Păduraru „Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania & General Surgery Department, University Emergency Hospital of Bucharest, Romania
  • Alexandra Bolocan “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania & General Surgery Department, University Emergency Hospital of Bucharest, Romania
  • O. Andronic „Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania & General Surgery Department, University Emergency Hospital of Bucharest, Romania
Keywords: perforated peptic ulcer, laparoscopy, peptic ulcer disease, open repair


Perforated peptic ulcer (PPU), a significant complication of peptic ulcer disease, has proven to be associated with high rates of mortality and morbidity and to this day, it remains a clear indication of emergency surgery. Whilst open repair remains a feasible treatment option for this complication, the development of laparoscopic surgery has brought along new perspectives, by revealing the benefits and drawbacks of this procedure and therefore raising the question whether it should be the first choice in treatment of a PPU. A literature search was performed using PubMed, Web of Science and Scopus, with the selection of relevant articles from the last 15 years. By comparing the two surgical approaches, conventional and laparoscopic, we aimed to identify the reasons laparoscopy is gaining ground as a mean of treatment of a PPU. Outcomes such as hospital stay, complication rates, use of postoperative analgesics and visual analogue scale favored laparoscopy. The most heterogeneous result was dictated by the operation time, which seems to correlate with multiple factors, a major one being the learning curve and skills this procedure requires. In addition, a significant number of papers had developed patient inclusion and exclusion criteria, which impacted the results of outcomes like morbidity and mortality. There is a lot of evidence that points to laparoscopy becoming the preferred method of treatment of a PPU, however further research is needed in order to reach a consensus.


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